The two teams spent much of the first period feeling each other out, with valid scoring opportunities at a premium.
Late in the first half, Belize winger Ashley Torres was sprung through, however, his touch let him down and Guatemalan goalkeeper Cristian Alvarez was able to collect without difficulty.
Just minutes later, Carlos Figueroa had a chance to put the Chapines ahead, but his shot from point blank range went straight at Belizean goalkeeper Woodrow West.
The second half proved a much more open affair. Both teams had numerous chances to get on the scoreboard, the best of which came when Guatemalan forward Minor Lopez saw West parry away his 67th minute effort from close range.
After a series of further close calls for Guatemala, Belize nearly got the winner through substitute Andres Makin, who ran onto a ball at the top of the box in the 82nd minute, but pushed his shot just wide.
West continued his stellar day by making another top notch save on a Lopez header as time wound down, preserving the tie and a valuable point for Belize, their first at the 2013 Copa Centroamericana.
The result left Guatemala winless in seven of its last eight UNCAF games, while Belize has three draws in its last five in the competition.
The point lifted the Guatemalans into sole possession of second place in Group A with two points, one behind leader Costa Rica. The two sides will meet on Tuesday.
Belize and Nicaragua have one point each, and will square-off against each other in two days.
To watch highlights of the Belize-Guatemala match, click here.